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Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

Lina N Zaripova1, Angela Midgley2, Stephen E Christmas3

  • 1Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.

Pediatric Rheumatology Online Journal
|August 24, 2021
PubMed

Insights

Juvenile idiopathic arthritis (JIA) is a complex paediatric inflammatory disease. Advances in understanding its pathogenesis and treatments offer improved outcomes, but further research is needed for non-responsive patients.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Inflammatory Diseases

Background:

  • Juvenile idiopathic arthritis (JIA) is the most common rheumatological condition in children.
  • JIA encompasses diverse subtypes based on clinical and serological criteria.

Purpose of the Study:

  • To review advances in JIA pathogenesis, including etiology, histopathology, and immunology.
  • To discuss current and emerging therapeutic strategies for JIA management.

Main Methods:

  • Literature review of JIA pathogenesis and treatment options.
  • Analysis of immunological changes associated with disease activity.
  • Evaluation of non-biologic and biologic disease-modifying anti-rheumatic drugs (DMARDs).

Main Results:

  • Significant progress in understanding JIA as a group of inflammatory diseases.
  • Improved clinical outcomes with advanced therapeutics, including biologics.
  • A subset of patients shows limited response to current treatments.

Conclusions:

  • Enhanced understanding of JIA pathogenesis is crucial for targeted therapies.
  • Further research is required to optimize treatment stratification and improve outcomes for all JIA patients.
  • Personalized treatment approaches are essential for managing JIA effectively.

Keywords:
Aetiology of juvenile idiopathic arthritisDisease-modifying anti-rheumatic drug treatmentJuvenile idiopathic arthritisPathogenesis of juvenile idiopathic arthritis

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