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Published on: September 1, 2020
Advanced technologies for the preservation of mammalian biospecimens
Haishui Huang1,2, Xiaoming He3,4,5, Martin L Yarmush6,7
1Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA. haishuihuang@xjtu.edu.cn.
Abstract:
The three classical core technologies for the preservation of live mammalian biospecimens-slow freezing, vitrification and hypothermic storage-limit the biomedical applications of biospecimens. In this Review, we summarize the principles and procedures of these three technologies, highlight how their limitations are being addressed via the combination of microfabrication and nanofabrication, materials science and thermal-fluid engineering and discuss the remaining challenges.
