Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.6K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.6K
Inflammatory Response01:28

Inflammatory Response

13.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
13.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

76.6K
Overview
76.6K
What is the Immune System?01:38

What is the Immune System?

119.3K
Overview
119.3K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.1K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.1K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

11.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
Same author

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity.

Science advances·2026
Same author

ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories.

Nature communications·2026
Same author

CNS1-dependent regulatory T cells shape recovery from acute lung injury.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells.

Nature immunology·2025
Same author

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Oct 23, 2025

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.0K

Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.

Wei Hu1, Zhong-Min Wang2,3, Yongqiang Feng2,4

  • 1Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. huw1@mskcc.org.

Nature Immunology
|August 24, 2021
PubMed
Summary

Regulatory T (Treg) cells prevent fatal autoimmune inflammation. Even during severe disease, restoring Treg cell function can normalize immune responses and reverse autoimmune conditions.

More Related Videos

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.9K
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

1.8K

Related Experiment Videos

Last Updated: Oct 23, 2025

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.0K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.9K
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

1.8K

Area of Science:

  • Immunology
  • Autoimmunity
  • T cell biology

Background:

  • Regulatory T (Treg) cells, dependent on Foxp3 expression, are crucial for preventing fatal autoimmune inflammation.
  • A key question is whether Treg cells remain functional amidst broad systemic inflammation that can impair their activity.

Purpose of the Study:

  • To investigate the functional capacity of Treg cells in established, severe autoimmune disease.
  • To determine if restoring Treg cell function can reverse established autoimmune pathology and provide long-term protection.

Main Methods:

  • Utilized a reversible Foxp3 null allele in mice with severe autoimmune disease.
  • Reinstated Foxp3 expression and Treg cell suppressor function in diseased mice.

Main Results:

  • Rescued Treg cells normalized immune activation and quelled severe tissue inflammation.
  • Restored Treg cell function reversed fatal autoimmune disease and provided long-term protection.
  • Demonstrated Treg cell functionality in the context of broad systemic inflammation.

Conclusions:

  • Treg cells are capable of functioning effectively even in established, severe inflammatory disease states.
  • Restoring Treg cell function can reset immune homeostasis and offer sustained protection against autoimmunity.