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Updated: Oct 23, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Voice Outcomes Following Colon Interposition.

Aishwarya Suresh1, Vishnu V Martha2, Robert T Sataloff3

  • 1Drexel University College of Medicine, Philadelphia, PA, USA.

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|August 24, 2021
PubMed
Summary

Colon interposition surgery can negatively affect voice and swallowing functions. This case study details issues like reflux and vocal cord paralysis, emphasizing the need for more research into these impacts.

Keywords:
colon interpositiondysphonialaryngopharyngeal refluxlarynxvoice

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Area of Science:

  • Otorhinolaryngology
  • Gastroenterology
  • Surgical Reconstruction

Background:

  • Colon interposition is a surgical technique used for esophageal reconstruction.
  • The mechanical and functional properties of the colon differ significantly from the native esophagus.
  • These differences may lead to complications affecting adjacent structures and functions.

Purpose of the Study:

  • To highlight the potential consequences of colon interposition on phonation and swallowing.
  • To present a case study detailing specific functional impairments post-surgery.
  • To underscore the need for further investigation into the mechanisms of these complications.

Main Methods:

  • Case report detailing a patient who underwent colon interposition.
  • Clinical assessment of phonation and swallowing functions.
  • Review of potential contributing factors to observed deficits.

Main Results:

  • The patient experienced laryngopharyngeal reflux.
  • Vocal fold paralysis was noted.
  • Impaired esophageal peristalsis and failed bolus transfers were observed.
  • Issues with voice and swallowing were attributed to the colon segment.

Conclusions:

  • Colon interposition can lead to significant phonation and swallowing problems.
  • Differences between colon and esophagus impact function, causing reflux and impaired transfer.
  • Further research is essential to understand and mitigate the effects of colon interposition on voice and swallowing.