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Updated: Oct 23, 2025

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Nickel-Catalyzed Hydroamination of Olefins with Anthranils
Yang Gao1, Yushan Cui1, Yanping Huo1
1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Abstract:
A nickel-catalyzed polarity-reversed hydroamination of olefins has been achieved with anthranils as the electrophilic aminating agents and hydrosilane as the reductant. This protocol provides a facile access to N-alkyl-2-aminobenzophenones that are versatile intermediates in organic synthesis. A wide range of olefins and anthranils are compatible in this transformation, delivering the desired amines in useful to excellent yields (38 examples, up to 92% yield). The utility of this protocol is exhibited in the late-stage functionalization of drug molecules and the valuable derivatives of the obtained amination products.
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