Giant Virus-Eukaryote Interactions as Ecological and Evolutionary Driving Forces

Giant DNA viruses of eukaryotes are notable for their extraordinary genome size and coding capacity. Once thought to be oddities in the virus world, these elusive microbes have turned out to be widely occurring in marine, freshwater, and terrestrial ecosystems and are commonly associated with diverse hosts, in particular microbial eukaryotes. This commentary discusses how new sequencing techniques and information can inform us about the interactions between giant viruses and eukaryotic hosts during the viral replication cycle and their implications for ecological and evolutionary processes across different spatiotemporal scales.