Related Experiment Video
Updated: Oct 23, 2025
09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
3.1K
[Lupus anticoagulant and ischemic strokes: about two case reports]
Julie Hilaire1, Clara Noizat1, Minh-Toan Duong1
1Service d'hématologie biologique, CRMR des MAT-laboratoire ADAMTS13, CRMR de la Maladie de Willebrand, Hôpital Lariboisière, AP-HP Nord, Université de Paris, Paris, France.
Annales De Biologie Clinique
|August 24, 2021
Summary
Antiphospholipid syndrome (APS) can cause ischemic stroke. Lupus anticoagulant (LA) testing is crucial for APS diagnosis in thrombotic events, requiring careful pathologist-clinician collaboration and specific assays.
Area of Science:
- Autoimmune diseases
- Hematology
- Neurology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder associated with thrombosis.
- Ischemic stroke is a significant clinical manifestation of APS.
- Lupus anticoagulant (LA) testing is a cornerstone for diagnosing APS.
Observation:
- Two cases of stroke in patients with LA are presented.
- The importance of clinician-pathologist collaboration in LA detection is highlighted.
- Awareness of potential interferences in LA testing is critical.
Findings:
- Accurate LA detection is vital for appropriate patient management in thrombotic settings.
- Specific and validated clotting assays are necessary for reliable LA screening.
- The study reviews the diagnostic strategy for LA screening.
Implications:
- Improved diagnostic strategies for LA can lead to better management of APS patients.
- Understanding LA interferences enhances diagnostic accuracy.
- Early and accurate diagnosis of APS can prevent recurrent thrombotic events.
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