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Updated: Oct 23, 2025

Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability
Tanveer Singh1,2, Awanish Mishra1,3, Rajesh Kumar Goel4
1Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, India.
Abstract:
Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.
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