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Involvement of miR-214-3p/FOXM1 Axis During the Progression of Psoriasis

Jin Zhao1, Fei Wang2, Qingjun Tian1

  • 1Department of Dermatology, Wuhan No 1 Hospital, Wuhan, China.

Inflammation
|August 24, 2021
PubMed

Insights

MicroRNAs (miRNAs) like miR-214-3p are crucial in psoriasis development. Targeting the miR-214-3p/FOXM1 pathway in skin cells offers a potential new treatment for psoriasis.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Genetics

Background:

  • Psoriasis is a chronic skin disease with unknown molecular drivers.
  • MicroRNAs (miRNAs) regulate gene expression and are implicated in psoriasis pathogenesis.

Purpose of the Study:

  • To investigate the role of miR-214-3p in psoriasis.
  • To explore the miR-214-3p/FOXM1 axis as a potential therapeutic target for psoriasis.

Main Methods:

  • Analysis of miRNA expression in psoriatic patients and mouse models.
  • In vitro studies using HaCaT cells to assess keratinocyte proliferation and cell cycle.
  • In vivo experiments using imiquimod (IMQ)-induced mice to evaluate therapeutic effects.

Main Results:

  • miR-214-3p was downregulated in psoriatic skin and IMQ-induced mouse models.
  • miR-214-3p inhibition promoted keratinocyte hyperproliferation and altered cell cycle gene expression.
  • miR-214-3p administration reduced psoriasis-like symptoms in mice.

Conclusions:

  • The miR-214-3p/FOXM1 axis plays a significant role in keratinocyte regulation.
  • Targeting this axis presents a novel therapeutic strategy for psoriasis treatment.
Keywords:
FOXM1;keratinocytes.miR-214-3p;psoriasis;

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