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Updated: Oct 23, 2025
05:27
Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
Published on: July 20, 2022
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The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology
Rishi Banerjee1,2, Janne Purhonen1,2, Jukka Kallijärvi1,2
1Folkhälsan Research Center, Helsinki, Finland.
The FEBS Journal
|August 24, 2021
Summary
Coenzyme Q (CoQ) links diverse metabolic pathways to mitochondrial respiration. This review explores CoQ
Area of Science:
- Mitochondrial biochemistry
- Cellular respiration
- Human pathology
Background:
- Coenzyme Q (CoQ) is crucial for electron transport in mitochondria.
- It accepts electrons from nine dehydrogenases involved in diverse metabolic pathways.
- CoQ reoxidation by mitochondrial complex III (CIII) is essential for energy production.
Purpose of the Study:
- To review the function of CIII.
- To explore the pathological consequences of CIII dysfunction.
- To discuss CoQ-dependent metabolism in human diseases.
Main Methods:
- Literature review
- Analysis of existing research on CIII and CoQ metabolism
- Discussion of experimental tools
Main Results:
- CoQ links numerous metabolic pathways, including amino acid and fatty acid oxidation, to the electron transport system.
- CIII dysfunction impacts CoQ homeostasis and cellular respiration.
- Limited literature exists on CoQ-linked metabolism in oxidative phosphorylation diseases.
Conclusions:
- CoQ-dependent metabolism plays a significant role in mitochondrial function and disease.
- Further research is needed to understand CoQ's role in oxidative phosphorylation disorders.
- Experimental tools are available to study compromised CoQ oxidation.
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