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Linderanoids A-O, dimeric sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm
Xin Liu1, Jing Fu2, Rong-Sheng Shen2
1State Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People's Republic of China; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, People's Republic of China.
Abstract:
Fifteen undescribed dimeric sesquiterpenoids, linderanoids A-O along with one known lindenane-type sesquiterpenoid dimer, lindenaneolide F, were isolated and identified from the roots of Lindera aggregata. Their structures and absolute configurations were elucidated using spectroscopy and electronic circular dichroism (ECD) analysis. All the isolated compounds were screened for transforming growth factor (TGF)-β inhibitory activity, and the results showed that linderanoid E significantly inhibited the TGF- β induced smad2 phosphorylation at a concentration of 25 μM.
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