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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
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A single-sided magnet for deep-depth fat quantification.

Ya Wang1, Yajie Xu2, Mingkang Zhang3

  • 1Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China; School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|August 24, 2021
PubMed
Summary
This summary is machine-generated.

A new, affordable, portable single-sided magnet enables early detection of fatty liver disease. This nuclear magnetic-resonance (NMR) system shows promise for non-invasive in vivo liver fat quantification, potentially preventing cirrhosis.

Keywords:
Liver fat quantificationMovableNMR relaxometrySingle-sided magnet

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Magnetic Resonance

Background:

  • Early detection of fatty liver disease is crucial to prevent progression to severe conditions like cirrhosis.
  • Current methods for liver fat quantification may have limitations in cost, portability, or accessibility.

Purpose of the Study:

  • To develop a low-cost, movable single-sided magnet system for in vivo liver fat quantification.
  • To assess the feasibility of using single-sided nuclear magnetic-resonance (NMR) relaxometry for non-invasive liver fat measurement.

Main Methods:

  • Structurally optimized a concave U-shaped magnet to achieve a gradient field of 73.5 G/cm and field strength of 0.0725 T.
  • Developed a prototype NMR relaxometry system utilizing the optimized single-sided magnet.
  • Evaluated system performance using proton density fat fraction (PDFF) phantoms.

Main Results:

  • Phantom experiments demonstrated the single-sided magnet's effectiveness in evaluating PDFF.
  • A good positive correlation was observed between PDFF and fitted fat amplitude across six phantoms.
  • The system successfully quantified liver fat in phantoms, indicating potential for in vivo application.

Conclusions:

  • Single-sided NMR relaxometry is a viable method for in vivo liver fat quantification.
  • The developed low-cost, portable system offers a promising approach for early fatty liver disease detection.
  • This technology could aid in preventing the progression of liver disease to cirrhosis.