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In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model
Maria Vitoria Oliveira Dantas1, Paula Lima Nogueira1, Filipe de Oliveira Lima1
1Federal University of Campina Grande, Patos, Paraíba, Brazil.
Objective:
The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats.
Materials And Methods:
Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel's solution and the control group SC with a 0.9% sodium chloride solution.
Statistical Analysis:
Data were submitted to the Kurskal-Wallis' test, followed by Dunn's post hoc (p < 0.05).
Results:
There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel's solution showed significant bleeding, six times greater than the control group SC.
Conclusion:
The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.
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