Unhealthy Opioid Use and COVID-19 Mortality Incidence in Older Adults: A Multicenter Research Network Study

Opioid use has the potential to influence infectious respiratory diseases. The purpose of this research is to examine if there is an association of deaths from the respiratory infection, COVID-19, and unhealthy opioid use in older adults.

Data about patients, ages ≥65 years, who had a COVID-19 infection between 1/20/2020 to 12/23/2020 (n = 533,153) were extracted using the TriNetX system. Mortality incidence between initial diagnosis and ninety days after contracting COVID-19 were determined. Comparisons were made between people with and without unhealthy opioid use.

There were 7,547 COVID-19 patients with unhealthy opioid use (mean age, 71.8 years; standard deviation 6.3 years) and 525,606 COVID-19 patients (mean age, 74.1 years; standard deviation 7.3 years) without unhealthy opioid use. Of the total, 15,852 (3.0%) died within 3 months of COVID-19 diagnosis. The unadjusted risk ratio of the cohort with unhealthy opioid use compared with the cohort that did not have unhealthy opioid uses was 1.18 (95% CI: 1.05,1.33); p = 0.0069. The relationship failed to remain significant in analysis with propensity score matching (risk ratio = 0.96; 95% CI: 0.82, 1.14; p = 0.6606, ns).

The public health implication is that although older adults are more vulnerable to COVID-19 than younger adults, a difference between older adults with or without unhealthy opioid use did not increase vulnerability to death from COVID-19 and should be not be considered if rationing of care becomes necessary.