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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Related Experiment Video

Updated: Oct 23, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2-triggered lymphocytic colitis.

Islam Osama Nassar1, Gerald Langman2, Mohammed Nabil Quraishi3,4

  • 1Gastroenterology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK Islam.Nassar@uhb.nhs.uk.

BMJ Case Reports
|August 25, 2021
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger inflammatory bowel disease (IBD). This case study highlights lymphocytic colitis developing after SARS-CoV-2, emphasizing the need for clinical vigilance in persistent diarrhea cases.

Keywords:
COVID-19gastrointestinal systeminfection (gastroenterology)inflammatory bowel disease

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Area of Science:

  • Gastroenterology
  • Virology
  • Immunology

Background:

  • Gastrointestinal infections are known triggers for inflammatory bowel diseases (IBD) in susceptible individuals.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has demonstrated tropism for the gastrointestinal tract.
  • IBD pathogenesis involves a dysregulated immune response to environmental factors in genetically predisposed hosts.

Observation:

  • A patient presented with chronic watery diarrhea following a SARS-CoV-2 infection.
  • Diagnostic work-up revealed a new diagnosis of lymphocytic colitis.

Findings:

  • The patient's symptoms resolved favorably after treatment with oral budesonide.
  • This case suggests a potential causal link between SARS-CoV-2 infection and the onset of lymphocytic colitis.

Implications:

  • Clinicians should consider IBD, specifically lymphocytic colitis, in patients experiencing persistent diarrhea after SARS-CoV-2 infection.
  • Increased vigilance for triggered IBD is warranted in the post-SARS-CoV-2 era.
  • Further research may elucidate the mechanisms by which viral infections precipitate IBD.