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LncRNA SNHG17 regulates cell proliferation and invasion by targeting miR-338-3p/SOX4 axis in esophageal squamous cell

Wenhu Chen1,2, Lifang Wang2, Xiaoyan Li2

  • 1Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Cell Death & Disease
|August 25, 2021
PubMed

Insights

Small nucleolar RNA host gene 17 (SNHG17) promotes esophageal squamous cell carcinoma (ESCC) progression by sponging miR-338-3p and upregulating SOX4. Inhibiting SNHG17 suppressed ESCC cell growth and invasion.

Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Biology

Background:

  • Small nucleolar RNA host gene 17 (SNHG17) is a long noncoding RNA implicated in various cancers.
  • The role of SNHG17 in esophageal squamous cell carcinoma (ESCC) remains largely uncharacterized.

Purpose of the Study:

  • To investigate the expression pattern and functional mechanisms of SNHG17 in ESCC.
  • To explore SNHG17 as a potential therapeutic target for ESCC.

Main Methods:

  • Quantitative real-time PCR to assess SNHG17 expression.
  • In vitro and in vivo experiments involving SNHG17 knockdown.
  • Bioinformatic analysis to predict miRNA interactions.
  • Luciferase reporter assays to validate miRNA-target interactions.

Main Results:

  • SNHG17 was significantly upregulated in ESCC tissues and cell lines.
  • SNHG17 knockdown inhibited ESCC cell proliferation, invasion, and epithelial-mesenchymal transition (EMT).
  • SNHG17 acted as a molecular sponge for miR-338-3p, leading to increased SOX4 expression.

Conclusions:

  • SNHG17 promotes ESCC progression through the SNHG17/miR-338-3p/SOX4 axis.
  • Targeting the SNHG17 pathway represents a potential therapeutic strategy for ESCC.

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