Related Experiment Video

Updated: Oct 23, 2025

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

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Catheter ablation of idiopathic outflow tract ventricular arrhythmias with low intraprocedural burden guided by pace

Richard Bennett1, Timothy Campbell1, Yasuhito Kotake1

  • 1Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre, University of Sydney, Westmead, Australia.

Heart Rhythm O2
|August 25, 2021
PubMed

Insights

Pace mapping (PM)-guided catheter ablation is effective for low-burden ventricular arrhythmias (VA), showing comparable outcomes to standard non-PM ablation. This strategy accurately identifies VA origin, offering similar success rates and reduced VA burden post-procedure.

Area of Science:

  • Electrophysiology
  • Cardiology
  • Medical Devices

Background:

  • Limited data exists comparing ablation outcomes for low vs. high intraprocedural burden of ventricular arrhythmias (VA).
  • Pace mapping (PM)-guided strategy for low VA burden is compared against standard activation mapping (non-PM) for high VA burden.

Purpose of the Study:

  • To determine if PM-guided catheter ablation for low-intraprocedural-burden idiopathic outflow tract VA is noninferior to non-PM-guided ablation.
  • To compare the efficacy and safety of two distinct mapping strategies in patients undergoing VA ablation.

Main Methods:

  • A comparative study involving 22 patients with low VA burden (PM-guided) and 44 patients with high VA burden (non-PM-guided).
  • Outcomes assessed included procedural duration, anesthesia use, fluoroscopy dose, complications, and 24-hour VA burden post-ablation.
  • Six-month VA-free survival was a key endpoint for comparing the two groups.

Main Results:

  • Procedural characteristics and complication rates were similar between PM-guided and non-PM-guided ablation groups.
  • Both groups demonstrated comparable 24-hour VA burden post-procedure (PM 0% vs. non-PM 0%, P = .98).
  • Six-month VA-free survival rates were also similar (PM 77% vs. non-PM 71%, P = .77).

Conclusions:

  • PM-guided catheter ablation accurately identifies the VA site of origin in patients with low intraprocedural burden.
  • Outcomes of PM-guided ablation are comparable to standard ablation techniques in this patient population.
  • This suggests PM guidance is a viable and effective strategy for specific VA ablation cases.
Abstract

Keywords:
Catheter ablationIdiopathicOutflow tractPace mappingVentricular arrhythmia

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