Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

84
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
84
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

167
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
167
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

156
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
156
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

121
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
121

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Ca<sup>2+</sup> Sequestration by the Sarco-/Endoplasmic Reticulum in Cardiac Purkinje Cells After Myocardial Infarction.

Cells·2026
Same author

Electrocardiographic Changes After Percutaneous Coronary Intervention for Chronic Total Occlusion.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

High Rates of Permanent Pacemaker Implantation After Left-Sided Cardiac Surgery in Adults with Congenital Heart Disease.

Heart rhythm·2026
Same author

Measure Twice, Ablate Once: When Discretion Proved the Better Part of Valor for Varipulse.

JACC. Clinical electrophysiology·2026
Same author

Enhanced Demographically Adaptive QT Correction Improves Pediatric Screening for Congenital Long QT Syndrome.

medRxiv : the preprint server for health sciences·2026
Same author

Photon-Counting Detector CT: Not Just New Technology, But an Entirely New Perspective.

AJR. American journal of roentgenology·2026

Related Experiment Video

Updated: Oct 23, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K

Adaptive Cardiac Resynchronization Therapy Effect on Electrical Dyssynchrony (aCRT-ELSYNC): A randomized controlled

Kazi T Haq1, Nichole M Rogovoy1, Jason A Thomas1,2

  • 1Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon.

Heart Rhythm O2
|August 25, 2021
PubMed
Summary

Adaptive cardiac resynchronization therapy (aCRT) similarly impacts electrical dyssynchrony as conventional CRT. However, aCRT uniquely reduces right ventricular uncoupling, improving interventricular dyssynchrony.

Keywords:
AV optimizationBundle branch blockCRTDyssynchronyECGIElectrocardiographic imagingHeart failureNoninvasive mappingRandomized controlled trialVentricular conduction abnormalities

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

1.1K
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.7K

Related Experiment Videos

Last Updated: Oct 23, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

1.1K
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.7K

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Adaptive cardiac resynchronization therapy (aCRT) offers clinical benefits over conventional CRT, yet underlying mechanisms require elucidation.
  • Understanding the impact of aCRT on cardiac electrical dyssynchrony is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To compare the effects of aCRT and conventional CRT on electrical dyssynchrony.
  • To investigate changes in ventricular electrical uncoupling (VEU) and electrical dyssynchrony index (EDI) post-therapy.

Main Methods:

  • A prospective, double-blind, randomized controlled trial involving 27 patients undergoing CRT.
  • Utilized cardiac computed tomography and 128-electrode body surface mapping for noninvasive electrocardiographic imaging.
  • Measured changes in VEU (LV vs. RV activation time difference) and EDI (SD of epicardial activation times) at baseline and 6 months.

Main Results:

  • Both aCRT and conventional CRT showed no significant difference in overall VEU and EDI changes.
  • aCRT demonstrated a significant reduction in VEU (18.9 ms, P=.034), unlike conventional CRT (P=.525).
  • Specific findings noted differences in conduction block patterns between typical and atypical left bundle branch block (LBBB).

Conclusions:

  • The impact of aCRT and conventional CRT on overall electrical dyssynchrony is comparable.
  • aCRT uniquely contributes to harmonizing interventricular dyssynchrony by effectively reducing right ventricular uncoupling.