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Decellularized human-sized pulmonary scaffolds for lung tissue engineering: a comprehensive review
Seyed Hossein Mahfouzi1, Seyed Hamid Safiabadi Tali1, Ghassem Amoabediny1,2
1Department of Biomedical Engineering, The Research Center for New Technologies in Life Science Engineering, University of Tehran, No. 4, Orouji all., 16 Azar St., 11155-4563, Tehran, Iran.
Regenerative Medicine
|August 25, 2021
Summary
Lung bioengineering aims to create transplantable lungs. This review covers decellularization and recellularization techniques for human-sized lung scaffolds, including stem cell use and transplantation outcomes.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Thoracic Surgery
Background:
- Lung transplantation is limited by donor scarcity.
- Bioengineering offers a potential solution for creating functional lungs.
- Large-scale lung bioengineering is critical for clinical application.
Purpose of the Study:
- To review advancements in decellularization and recellularization of human-sized lung scaffolds.
- To assess the potential of bioengineered lungs for transplantation.
- To identify challenges and future directions in lung bioengineering.
Main Methods:
- Review of studies on decellularization enhancement for large lungs.
- Analysis of xenogeneic lung scaffold sources.
- Evaluation of decellularization/recellularization of diseased lung scaffolds.
- Assessment of stem cell applications in recellularization.
- Review of bioengineered lung transplantation case studies.
Main Results:
- Progress in decellularization techniques for large-scale lungs.
- Exploration of various xenogeneic sources for lung scaffolds.
- Demonstrated feasibility of decellularizing and recellularizing diseased lungs.
- Identification of stem cell types for effective recellularization.
- Early-stage success in bioengineered lung transplantation.
Conclusions:
- Significant progress has been made in lung bioengineering.
- Further research is needed to overcome challenges in scaffold quality and vascularization.
- Stem cell integration and functional assessment are key areas for future development.
- Clinical translation of bioengineered lungs is a promising but complex endeavor.
