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Published on: February 28, 2014
Brief Synopsis: "Instruction Manual for Juvenile Clinical Pathology"
Anne Provencher1, Paula Katavolos2
1Global Safety Assessment, 70294Charles River Laboratories, Sherbrooke, Quebec, Canada.
Abstract:
This symposium synopsis summarizes key points discussed related to clinical pathology data interpretation for reproduction and juvenile toxicology studies. In pregnant and growing animals, several changes in clinical pathology parameters linked to growth/maturation of organ and physiological functions can occur, and understanding these changes is important to enable accurate interpretation of clinical pathology data. A brief overview of the general approach to clinical pathology data analysis according to contemporary practices is provided, followed by a discussion focused specifically on reproductive and juvenile clinical pathology. In this context, the approach to recognize and differentiate changes that may be related to pregnancy and growth as opposed to those that may be related to test article effects is highlighted.
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