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Related Experiment Video

Updated: Oct 23, 2025

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Dissociation between exercise intensity thresholds: mechanistic insights from supine exercise.

Richie P Goulding^1,2,3, Simon Marwood⁴, Tze-Huan Lei⁵

¹Laboratory for Myology, Vrije Universiteit, Amsterdam, The Netherlands.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

|August 25, 2021

Summary

The respiratory compensation point (RCP) and deoxygenated [heme] breakpoint (deoxy[heme]_BP) do not consistently occur at the same metabolic intensity during exercise. These physiological markers can differ between muscles and body positions, suggesting distinct underlying mechanisms.

Keywords:

deoxy- + total (hemoglobin + myoglobin)exercise intensity thresholds respiratory compensation point supine exercise time-resolved near-infrared spectroscopy

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Last Updated: Oct 23, 2025

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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

Exercise Physiology
Muscle Physiology
Biomedical Engineering

Background:

The respiratory compensation point (RCP) is a key indicator of exercise intensity.
Near-infrared spectroscopy (NIRS) measures changes in muscle oxygenation.
Understanding muscle oxygenation during exercise is crucial for performance and health.

Purpose of the Study:

To test if the RCP and deoxy[heme]_BP occur at the same metabolic rate in upright and supine positions.
To investigate the relationship between RCP, deoxy[heme]_BP, and muscle activity during incremental exercise.
To determine if body position affects these physiological markers.

Main Methods:

Eleven healthy men performed ramp incremental exercise tests in upright and supine positions.
Gas exchange was measured breath-by-breath.
Time-resolved NIRS measured deoxy[heme] in the vastus lateralis and rectus femoris muscles.

Main Results:

RCP differed from deoxy[heme]_BP in the vastus lateralis in the upright position.
Deoxy[heme]_BP varied between muscles and was not consistently related to RCP changes between positions.
Deoxy[heme]_BP was preceded by breakpoints in total [heme] and muscle EMG.

Conclusions:

RCP and deoxy[heme]_BP can be dissociated across muscles and body positions.
These markers do not represent the same physiological phenomenon during exercise.
Deoxy[heme]_BP may be mechanistically linked to changes in total [heme] and muscle activity.