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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Breast cancer therapy and bone.

Z Stevens1, J Hellig2

  • 1Department of Endocrinology, Christiaan Barnard Memorial Hospital, Cape Town, South Africa.

Climacteric : the Journal of the International Menopause Society
|August 25, 2021
PubMed
Summary

Breast cancer treatments can cause bone loss. Osteoporosis therapies like bisphosphonates help prevent fractures and may aid in preventing cancer recurrence.

Keywords:
Breast canceraromatase inhibitorbisphosphonatesbone lossdenosumabosteoporosis

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Area of Science:

  • Oncology
  • Endocrinology
  • Bone Metabolism

Background:

  • Breast cancer is a leading cause of mortality in women.
  • Cancer therapies, particularly those causing estrogen deprivation, significantly increase fracture risk due to bone density loss.
  • Cancer therapy-induced bone loss (CTIBL) is a critical concern for breast cancer patients.

Purpose of the Study:

  • To review the role of anti-resorptive osteoporosis therapies in mitigating CTIBL.
  • To evaluate the potential of these therapies as adjuvant treatment for breast cancer recurrence.
  • To highlight the importance of bone health management in breast cancer care.

Main Methods:

  • Review of current international guidelines for CTIBL management.
  • Analysis of evidence supporting bisphosphonates (zoledronic acid, clodronate) and denosumab for bone health in breast cancer patients.
  • Assessment of the evolving role of bone-targeted therapies in adjuvant breast cancer treatment.

Main Results:

  • Anti-resorptive therapies, including bisphosphonates and denosumab, are crucial for managing CTIBL.
  • Evidence supports zoledronic acid and clodronate as effective adjuvant therapies for moderate to high-risk breast cancer to prevent recurrence.
  • Guidelines exist for treatment thresholds based on bone density and clinical risk factors.

Conclusions:

  • Bone-targeted therapies play a vital role in preserving bone density and reducing fracture risk in breast cancer patients undergoing treatment.
  • The use of bisphosphonates as adjuvant therapy in breast cancer is supported by current evidence.
  • Prioritizing bone health is essential for women with breast cancer to prevent debilitating bone loss and fractures.