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Related Experiment Videos

A clinically significant interaction between ciprofloxacin and theophylline.

A H Thomson1, G D Thomson, M Hepburn

  • 1Department of Materia Medica, University of Glasgow, UK.

European Journal of Clinical Pharmacology
|January 1, 1987
PubMed
Summary

Ciprofloxacin significantly reduces theophylline clearance, leading to potential toxicity. Discontinuing ciprofloxacin restores normal theophylline metabolism, highlighting a critical drug interaction to manage.

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Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Theophylline is a medication used to treat respiratory diseases.
  • Drug interactions can alter the metabolism and clearance of medications.

Observation:

  • A patient experienced theophylline toxicity.
  • This occurred after the co-administration of ciprofloxacin.

Findings:

  • Theophylline clearance decreased from 2.3 L/h to 0.8 L/h with ciprofloxacin.
  • Theophylline clearance returned to 2.1 L/h after ciprofloxacin was stopped.

Implications:

  • Ciprofloxacin is a potent inhibitor of theophylline metabolism.
  • Clinicians should monitor theophylline levels closely when co-administering with ciprofloxacin.

Related Experiment Videos

  • This interaction necessitates careful drug regimen adjustments in patients receiving theophylline.