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Updated: Oct 23, 2025

Author Spotlight: Advancing 3D Cell Modeling – A High-Throughput Approach for Neural Cocultures
Published on: September 29, 2023
A protein-centric view of in vitro biological model systems for schizophrenia
Abinaya Chandrasekaran1, Pia Jensen2, Fadumo A Mohamed1
1Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract:
Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.
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