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Updated: Oct 23, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
[Potentiation of weight reduction with GLP-1 receptor agonists]
André J Scheen1,2, Nicolas Paquot1
1Service de diabétologie, nutrition et maladies métaboliques, CHU Liège, Liège Université, 4000 Liège, Belgique.
Abstract:
Glucagon-like peptide-1 receptor agonists are the antidiabetic agents that are associated with the greatest weight loss beyond a marked reduction in glycated haemoglobin. Weight loss results from a reduction in appetite through a predominant central effect combined with a peripheral effect. Liraglutide and semaglutide are developed for the treatment of obesity, independently of type 2 diabetes. Three approaches may be considered to potentiate weight loss: an increase of the drug dosage because of the demonstration of a dose-response, an add-on therapy with a sodium-glucose cotransporter type 2 inhibitor as this agent exerts a complementary action through urinary calorie loss (glucosuria) or a combination of the effects of two incretin hormones (GLP-1 and GIP), as the potent dual agonist tirzepatide currently in development.
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