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Effective Oral RNA Interference RNAi Administration to Adult Anopheles gambiae Mosquitoes

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Intraspecific Transcriptome Variation and Sex-Biased Expression in Anopheles arabiensis.

Vivek Jayaswal¹, Cyrille Ndo², Hsiu-Ching Ma³

¹School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.

Genome Biology and Evolution

|August 25, 2021

Summary

This summary is machine-generated.

Intraspecific transcriptional variation in Anopheles arabiensis, a malaria vector, reveals extensive adaptive potential. Female-biased genes show the most interpopulation variation, suggesting a key role in adaptation.

Keywords:

Anopheles arabiensis faster-X effect functional diversification sex-biased gene expression transcriptome variation

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Area of Science:

Genomics
Evolutionary Biology
Entomology

Background:

Intraspecific transcriptional variation in anophelines, particularly sex-biased genes, is understudied.
Understanding expression level changes is crucial for comprehending adaptation in malaria vectors.

Purpose of the Study:

To investigate the magnitude and patterns of intraspecific transcriptional variation in Anopheles arabiensis.
To explore how expression changes drive adaptation in this key malaria vector.

Main Methods:

Sequencing of female, male, and larval transcriptomes from three Anopheles arabiensis populations in Burkina Faso.
Differential gene expression analysis between populations and sample types.
Genomic analysis of gene expression variation across chromosomes and gene classes.

Main Results:

One-third of genes showed differential expression between populations, with insecticide resistance genes frequently involved.
Females exhibited the largest number of differentially expressed genes.
Female-biased genes displayed greater interpopulation variation than male-biased genes.

Conclusions:

Anopheles arabiensis possesses extensive adaptive potential through transcriptional variation.
The X chromosome shows a higher evolutionary rate of expression changes than autosomes.
Female-biased genes represent the most variable component of the Anopheles arabiensis transcriptome.