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An experimental study of quinine blindness
T A Buchanan1, R W Lyness, A D Collins
1Department of Ophthalmology, Royal Victoria Hospital, Belfast, Northern Ireland.
Eye (London, England)
|January 1, 1987
Summary
Quinine can cause blindness, with recovery depending on the dose. This study concludes quinine is directly toxic to the retina, not due to lack of blood flow.
Area of Science:
- Ophthalmology
- Toxicology
- Neuroscience
Background:
- Quinine is a medication with known ocular side effects.
- Understanding the mechanism of quinine-induced vision impairment is crucial for patient safety.
Purpose of the Study:
- To develop an experimental model for quinine-induced blindness.
- To investigate the relationship between quinine dosage and visual function.
- To elucidate the underlying mechanisms of quinine's effect on the retina.
Main Methods:
- Establishment of an experimental model for quinine-induced vision impairment.
- Performance of electrophysiological, angiographical, and morphological examinations.
- Dose-response analysis of quinine effects on blindness and recovery.
Main Results:
- Blindness and recovery were dose-dependent.
- No evidence of acute retinal ischemia was observed.
- Morphological and electrophysiological changes indicated direct retinal toxicity.
Conclusions:
- Quinine is directly retinotoxic.
- The mechanism of quinine-induced blindness does not involve acute retinal ischemia.
- This model aids in understanding and potentially mitigating quinine's ocular toxicity.