Related Experiment Video
Updated: Oct 23, 2025

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Anatomical consideration of deep calf veins: application to catheter-directed thrombolysis
Kyu-Ho Yi1,2, Jong-Jin Lee2,3, Hye-Won Hur2
1Wonju Public Health Center, COVID-19 Division, Wonju-Si, Korea.
Insights
The proximal posterior tibial vein and anterior tibial vein offer the best venous access for antegrade catheter-directed thrombolysis due to their larger diameters and surface areas, unlike smaller calf veins.
Area of Science:
- Vascular anatomy
- Interventional radiology
Background:
- Antegrade approach is common for deep vein thrombosis (DVT) catheter-directed thrombolysis.
- Accessing small diameter veins can be challenging for this procedure.
- Understanding deep calf vein variations is crucial for optimal access.
Purpose of the Study:
- To determine the most suitable deep calf veins for venous access in antegrade catheter-directed thrombolysis.
- To analyze the anatomical variations of key deep calf veins.
Main Methods:
- Dissection of 132 Korean and Thai cadaver legs.
- Measurement of diameters and surface areas of proximal and distal posterior tibial, peroneal, and anterior tibial veins.
- Scanning and measurement of selected veins.
Main Results:
- Proximal posterior tibial vein had the largest mean diameter (6.34 mm) and surface area (0.312 cm²).
- Anterior tibial vein also showed significant size (5.22 mm diameter, 0.213 cm² surface area).
- Distal posterior tibial and peroneal veins were smaller and less suitable for access.
Conclusions:
- Proximal posterior tibial and anterior tibial veins are ideal for antegrade thrombolysis access.
- Distal posterior tibial and peroneal veins are not recommended due to smaller dimensions and anatomical variability.
Purpose:
An antegrade approach is frequently used in catheter-directed thrombolysis to remove deep-vein thrombosis. However, the antegrade approach is difficult when accessing veins with small diameters; therefore, understanding the variation of deep calf vein is important.
Methods:
This study measured the diameters and surface areas of the proximal and distal posterior tibial vein, peroneal vein, and anterior tibial vein to determine which are preferable for venous access. This study dissected 132 legs from Korean and Thai cadavers. The proximal and distal posterior tibial vein, peroneal vein, and anterior tibial vein were scanned and measured.
Results:
The mean diameter and surface area were largest for the proximal tibial vein, at 6.34 mm and 0.312 cm2, respectively, followed by the anterior tibial vein (5.22 mm and 0.213 cm2), distal posterior tibial vein (3.29 mm and 0.091 cm2), and peroneal vein (3.43 mm and 0.081 cm2). The proximal posterior tibial vein and anterior tibial vein have large diameters and surface areas, which make them ideal for applying an antegrade approach in catheter-directed thrombolysis.
Conclusions:
The distal posterior tibial vein and peroneal vein are not recommended due to their smaller surface areas and also the anatomical variations therein.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Veins of Lower Limbs
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
Venous Thrombosis I: Introduction
Venous Thrombosis IV: Nursing Management
Varicose Veins II: Diagnostic Studies and Interprofessional Care

