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Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway
Xin Huang1, Min-Zhou Zhang2, Bo Liu3
1Intensive Care Research Team of Traditional Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, the Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Chinese Journal of Integrative Medicine
|August 25, 2021
Summary
Astragaloside IV (AST) significantly improved survival rates and cardiac function in rats with sepsis-induced myocardial injury. AST protected the heart by reducing apoptosis and inflammation, potentially through the IKK/NF-κB pathway.
Area of Science:
- Cardiovascular Research
- Sepsis Pathophysiology
- Pharmacology
Background:
- Sepsis-induced cardiac dysfunction is a major cause of mortality.
- Cecal ligation and puncture (CLP) is a common model for inducing sepsis.
- Astragaloside IV (AST) is a potential therapeutic agent.
Purpose of the Study:
- To evaluate the cardioprotective effects of Astragaloside IV (AST) in a rat model of sepsis-induced myocardial injury (CLP).
Main Methods:
- Rats underwent CLP surgery to induce sepsis.
- Rats were treated with AST (40 mg/kg) or saline.
- Cardiac function, inflammatory mediators, oxidative stress markers, myocardial apoptosis, and protein levels (Bcl-2, Bax, IKKα, NF-κB p65) were assessed.
Main Results:
- AST improved survival rates by 33.3% in CLP-induced rats.
- AST enhanced cardiac function (ejection fraction, fractional shortening) and reduced myocardial apoptosis.
- AST attenuated inflammatory cytokines (IL-6, IL-10, HMGB-1), oxidative stress markers (SOD, MDA), and suppressed IKK-α and NF-κB p65 phosphorylation.
Conclusions:
- AST demonstrates significant cardioprotective effects in sepsis-induced cardiac dysfunction.
- AST improves survival outcomes in sepsis models.
- The cardioprotection mechanism involves the IKK/NF-κB pathway in cardiomyocytes.
