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Mitochondrial stress response in drug-induced liver injury

Jing Zheng1,2, Qiulin Yuan1, Cao Zhou1

  • 1Department of Microbiology and Immunology, The Institute of Infection and Inflammation, Medical College, China Three Gorges University, No. 8 DaXue Road, Yichang, 443002, Hubei, China.

Molecular Biology Reports
|August 25, 2021
PubMed

Insights

Drug-induced liver injury (DILI) involves reactive metabolites damaging mitochondria. The mitochondrial stress response may offer protective effects against DILI, guiding clinical treatments.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Toxicology

Background:

  • Drug-induced liver injury (DILI) is a common health issue stemming from various ingested substances.
  • DILI mechanisms involve reactive metabolites, mitochondrial oxidative stress, and permeability transition pore opening, leading to cell death.
  • Mitochondria are vital for cellular ATP production and signaling, but susceptible to drug-induced impairment.

Purpose of the Study:

  • To review current research on the protective role of the mitochondrial stress response in DILI.
  • To explore potential mechanisms underlying the protective effects of mitochondrial stress response in DILI.
  • To offer insights for the clinical management of DILI.

Main Methods:

  • Literature review of frontier research on mitochondrial stress response in DILI.
  • Analysis of studies detailing the mechanisms of DILI and mitochondrial involvement.
  • Synthesis of findings to connect mitochondrial stress response to DILI protection.

Main Results:

  • Mitochondrial stress response acts as an adaptive mechanism against cellular damage when homeostasis is threatened.
  • Drug-induced stress can impair mitochondrial function, but the stress response may mitigate this.
  • Research highlights the potential of targeting mitochondrial pathways for DILI treatment.

Conclusions:

  • The mitochondrial stress response shows promise as a protective factor against DILI.
  • Understanding these mechanisms can inform novel therapeutic strategies for DILI.
  • Further research into mitochondrial protection could revolutionize DILI treatment.
Keywords:
Adaptive protective mechanismDrug-induced liver injuryMitochondrial homeostasisMitochondrial stress response

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