Constitutional Dynamic Selection at Low Reynolds Number in a Triple Dynamic System: Covalent Dynamic Adaptation...

Area of Science:

• Supramolecular Chemistry
• Dynamic Covalent Chemistry
• Materials Science

Background:

• Dynamic covalent chemistry (DCC) and supramolecular self-assembly are key for creating adaptive materials.
• Complex systems require precise control over component interactions and organization.

Purpose of the Study:

• To design and investigate a triple dynamic complex system integrating DCC and supramolecular self-assembly.
• To explore the self-organization-driven constitutional adaptation and tunable composition of the system.

Main Methods:

• Established two dynamic covalent libraries (DCL-1 and DCL-2) based on C═C/C═N organo-metathesis.
• Utilized barbituric acid-based Knoevenagel constituents for sequential self-organization into supramolecular polymers (SPs) and gels.
• Investigated temperature and solvent effects on DCL-2 distribution patterns.

Main Results:

• The system demonstrated selective self-organization-driven amplification leading to SP formation.
• Heating caused reversible dissociation and randomization of SP constituents.
• Tunable composition was achieved through coupled dynamic covalent component selection and two-stage supramolecular organization.

Conclusions:

• The designed triple dynamic complex system exhibits remarkable self-organization-driven constitutional adaptation.
• The system's tunable composition highlights the interplay between dynamic covalent chemistry and supramolecular organization.
• These findings offer insights into dynamic adaptation mechanisms relevant to low Reynolds number conditions in living systems.