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Pre-diagnosis thyroid hormone dysfunction is associated with cancer mortality.
Eilon Krashin1,2, Barbara Silverman3,4, David M Steinberg5
1Translational Oncology Laboratory, Meir Medical Center, Kfar-Saba, Israel.
Endocrine-Related Cancer
|August 25, 2021
Summary
Pre-diagnosis thyroid dysfunction, including abnormal thyroid stimulating hormone (TSH), free T4 (FT4), and free T3 (FT3) levels, is linked to higher cancer mortality. This association is particularly evident in specific cancers like melanoma.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Limited and inconclusive research exists on the link between thyroid hormone levels and cancer mortality.
- Thyroid hormones play crucial roles in cellular metabolism and function, potentially influencing cancer development and progression.
Purpose of the Study:
- To investigate the association between pre-diagnostic thyroid stimulating hormone (TSH), free T4 (FT4), and free T3 (FT3) levels and overall cancer mortality.
- To examine the relationship between TSH levels and mortality in specific cancer types, including melanoma.
Main Methods:
- Retrospective cohort study of 10,325 Israeli cancer patients diagnosed between 2000-2016.
- Exclusion of patients treated with thyroid-altering medications.
- Multivariate-adjusted Cox proportional hazards models used to assess hazard ratios (HRs) for cancer mortality based on thyroid hormone function.
Main Results:
- Hypothyroid ranges of TSH, FT4, and FT3 were associated with increased overall cancer mortality (adjusted HRs 1.20, 1.74, 1.87, respectively).
- TSH levels in both hyperthyroid and hypothyroid ranges were significantly associated with increased melanoma mortality (adjusted HRs 2.20, 4.47, respectively).
Conclusions:
- Pre-diagnostic thyroid dysfunction is associated with elevated cancer mortality, with specific cancer types driving this relationship.
- Thyroid hormone levels may serve as potential prognostic markers for cancer patients.
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