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ARE THERE TWO FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME?

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroidopathy

Background:

  • Multiple Evanescent White Dot Syndrome (MEWDS) is an inflammatory condition affecting the retina.
  • Differentiating primary MEWDS from secondary forms is crucial for understanding its etiology.

Purpose of the Study:

  • To analyze the characteristics of secondary MEWDS.
  • To distinguish secondary MEWDS from idiopathic MEWDS.

Main Methods:

  • Evaluation of 20 consecutive patients with secondary MEWDS.
  • Utilized multimodal imaging: color fundus photography, autofluorescence, fluorescein angiography, indocyanine green angiography, SD-OCT, and OCT angiography.

Main Results:

  • Secondary MEWDS predominantly affected young adult females with myopia.
  • Associated conditions included high myopia, post-vitreoretinal surgery, and multifocal choroiditis.
  • MEWDS lesions resolved independently of the underlying pathology.

Conclusions:

  • Secondary MEWDS is proposed as an epiphenomenon (EpiMEWDS).
  • It is associated with conditions that disrupt the choriocapillaris-Bruch membrane-retinal pigment epithelium complex.