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Biodegradable macromers for implant bulk and surface engineering.

Jan Krieghoff1,2, Mathis Gronbach1,2, Michaela Schulz-Siegmund1,2

  • 1Medical Faculty, Pharmaceutical Technology, Leipzig University, Eilenburger Str. 15A, D-04317 Leipzig, Germany.

Biological Chemistry
|August 25, 2021
PubMed
Summary
This summary is machine-generated.

Biodegradable macromers offer tunable properties for tissue regeneration implants. Design flexibility and advanced processing enable tailored solutions for hard and soft tissue repair, focusing on bone regeneration applications.

Keywords:
biodegradable polymeric blocksimplant surface modificationporous scaffoldsregenerative medicinetissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Macromers are polymeric molecules with multiple functional groups, enabling tailored mechanical, biochemical, and degradative properties for tissue regeneration implants.
  • Biodegradable macromers, incorporating at least one degradable block, offer versatile design options for biomaterials.
  • These materials can be processed into implants using additive manufacturing, molding, and templating techniques.

Purpose of the Study:

  • To review the concept of biodegradable macromers for tissue regeneration.
  • To discuss recent advancements in macromer processing into implants.
  • To highlight surface modification techniques for bone regeneration applications.

Main Methods:

  • Review of existing literature on biodegradable macromers and their applications.
  • Discussion of macromer design, including polymeric blocks, core molecules, and reactive groups.
  • Analysis of cross-co-polymerization strategies with anchor or linker molecules.
  • Examination of additive manufacturing, molding, and templating for implant fabrication.
  • Focus on surface modification techniques for bone regeneration.

Main Results:

  • Biodegradable macromers provide a versatile platform for creating customized biomaterials for tissue regeneration.
  • A wide range of design choices allows adaptation for specific hard and soft tissue applications.
  • Advanced processing techniques, including additive manufacturing, enable the fabrication of complex implant structures.
  • Surface modification strategies are crucial for enhancing implant performance, particularly in bone regeneration.

Conclusions:

  • Biodegradable macromers are highly adaptable materials for developing advanced implants in tissue engineering.
  • The design flexibility and processing options allow for precise tuning of material properties for diverse regenerative needs.
  • Further research and development in macromer-based biomaterials hold significant promise for improving bone regeneration therapies.