Coronary artery thrombus resulting in ST-elevation myocardial infarction in a patient with COVID-19
Clara Green1, Adnan Nadir2, Will Lester3
1Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK clara.green@nhs.net.
Insights
This case highlights that COVID-19 can cause coronary artery thrombosis, leading to ST-elevation myocardial infarction (STEMI). Management may differ from typical STEMI cases, emphasizing thrombus removal over stenting.
Area of Science:
- Cardiology
- Infectious Diseases
- Vascular Medicine
Background:
- COVID-19 is recognized as a prothrombotic state.
- Myocardial damage and elevated troponin levels are observed in COVID-19 patients.
- Acute coronary syndromes can occur in the context of SARS-CoV-2 infection.
Observation:
- A 54-year-old male with COVID-19 presented with respiratory failure.
- The patient developed a ST-elevation myocardial infarction (STEMI) during hospitalization.
- Coronary angiography revealed a heavily thrombosed right coronary artery with no significant atherosclerotic disease.
Findings:
- Successful revascularization of the thrombosed right coronary artery was achieved via thrombus retrieval and manual thrombectomy, without stenting.
- Intracoronary thrombolysis was employed due to the heavy thrombus burden.
- Post-procedure, the patient was managed with triple antithrombotic therapy, including an oral anticoagulant and dual antiplatelets.
Implications:
- This case underscores the link between COVID-19 and coronary artery thrombosis.
- Management of STEMI in COVID-19 patients may necessitate strategies focused on thrombus burden, differing from atherosclerotic causes.
- Further research into COVID-19-associated thrombotic events and their specific therapeutic approaches is warranted.
Abstract:
COVID-19 is a prothrombotic condition that is also associated with raised troponin levels and myocardial damage. We present a case of a 54-year-old man who was admitted with respiratory failure due to COVID-19 and developed a ST-elevation myocardial infarction (STEMI) during his admission. His coronary angiogram did not show any significant coronary artery disease other than a heavily thrombosed right coronary artery. In view of heavy thrombus burden, the right coronary artery was treated with thrombus retrieval using a distal embolic protection device in addition to manual thrombectomy and direct (intracoronary) thrombolysis without the need for implantation of a coronary stent. After successful revascularisation, triple antithrombotic therapy was instituted with an oral anticoagulant in addition to dual antiplatelets. This case illustrates the association of COVID-19 with coronary artery thrombosis, which may require disparate management of a STEMI than that resulting from atherosclerotic coronary artery disease.
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