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Related Experiment Video

Updated: Oct 23, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Neonatal MIS-C: Managing the Cytokine Storm.

Sumita Saha1, Priyankar Pal2, Devdeep Mukherjee3

  • 1Fortis Hospital, Anandapur, Kolkata, India sumitas74@gmail.com.

Pediatrics
|August 26, 2021
PubMed
Summary
This summary is machine-generated.

A newborn developed severe multisystem inflammatory syndrome in children (MIS-C) following COVID-19 infection. This rare case highlights refractory myocarditis, gastrointestinal, and renal issues in neonatal MIS-C.

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Area of Science:

  • Neonatology
  • Pediatric Infectious Diseases
  • Critical Care Medicine

Background:

  • Late-onset sepsis and persistent thrombocytopenia were initially diagnosed in a term infant.
  • The infant presented with recurrent fever, diarrhea, and a maculopapular rash, prompting further investigation.

Observation:

  • COVID-19 infection was confirmed via RT-PCR in the infant.
  • The infant rapidly developed cardiogenic shock, pulmonary edema, anemia, and thrombocytopenia, requiring mechanical ventilation.

Findings:

  • Diagnosis of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 was made.
  • The infant experienced seizures, pulmonary hemorrhage, cardiac arrest, and acute kidney injury, indicating severe systemic involvement.
  • Refractory myocarditis, gastrointestinal, and renal manifestations were prominent features of this neonatal MIS-C case.

Implications:

  • This case underscores the potential for severe, multi-organ system disease in neonates with COVID-19.
  • It highlights the diagnostic challenges and critical care needs in neonatal MIS-C.
  • The unique dermatologic manifestations in neonatal COVID-19 warrant further study.