Related Experiment Video
Updated: Oct 23, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Distal Radial Access in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO
Ilias Nikolakopoulos, Taral Patel, Brian K Jefferson
1Minneapolis Heart Institute, 920 E. 28th Street #300, Minneapolis, MN 55407 USA. esbrilakis@gmail.com.
Insights
Distal radial access (dRA) for chronic total occlusion percutaneous coronary intervention (CTO-PCI) shows similar success and complication risks compared to proximal radial access (pRA). dRA also led to lower radiation doses and reduced tamponade rates in this study.
Area of Science:
- Interventional Cardiology
- Vascular Access Techniques
- Cardiovascular Interventions
Background:
- Limited studies exist on distal radial access (dRA) outcomes for chronic total occlusion percutaneous coronary intervention (CTO-PCI).
- Radial artery access is increasingly preferred for PCI due to lower complication rates compared to femoral access.
Purpose of the Study:
- To compare the clinical, angiographic, and procedural outcomes of CTO-PCI performed via dRA versus proximal radial access (pRA).
- To evaluate the safety and efficacy of dRA in the context of complex PCI procedures.
Main Methods:
- A large, multicenter registry study compared 120 CTO-PCIs using dRA with 2625 CTO-PCIs using pRA.
- Clinical, angiographic, and procedural characteristics were analyzed, including PROGRESS-CTO and J-CTO scores.
- Technical success rates and major periprocedural adverse cardiac events were assessed.
Main Results:
- Technical success rates were similar between dRA (90%) and pRA (86%).
- The incidence of major adverse cardiac events was comparable (0.8% vs 2.4%).
- dRA was associated with significantly lower rates of tamponade requiring pericardiocentesis (0% vs 4.69%) and reduced air kerma radiation dose (median 1.7 Gy vs 2.27 Gy).
Conclusions:
- Distal radial access (dRA) is a viable and safe alternative to proximal radial access (pRA) for CTO-PCI.
- dRA offers comparable procedural success with a potentially lower risk of specific complications like tamponade and reduced radiation exposure.
Background:
The outcomes of distal radial access (dRA) in chronic total occlusion percutaneous coronary intervention (CTO-PCI) have received limited study.
Methods:
We compared the clinical, angiographic, and procedural characteristics of 120 CTO-PCIs performed via dRA access with 2625 CTO-PCIs performed via proximal radial access (pRA) in a large, multicenter registry.
Results:
The dRA group had lower mean PROGRESS-CTO score than the pRA group (1.0 ± 1 vs 1.2 ± 1, respectively; P=.05), while J-CTO score (2.4 ± 1.2 vs 2.3 ± 1.3; P=.43) and PROGRESS-CTO Complications score (2.8 ± 1.8 vs 2.6 ± 1.9; P=.16) were similar in the dRA vs pRA groups, respectively. Technical success was similar in the 2 groups (90% dRA vs 86% pRA; P=.14). Concomitant use of femoral access did not alter procedural success. The incidence of major periprocedural adverse cardiac events was similar in the 2 groups (0.8% dRA vs 2.4% pRA; P=.26), whereas the incidence of tamponade requiring pericardiocentesis was lower with dRA (0% dRA vs 4.69% pRA; P<.001), as was air kerma radiation dose (median, 1.7 Gy; interquartile range [IQR], 0.97-2.63 Gy in the dRA group vs median, 2.27 Gy; IQR, 1.2-3.9 Gy in the pRA group; P<.001).
Conclusions:
Use of dRA in CTO-PCI is associated with similar procedural success and risk of complications as compared with pRA.
More Related Videos
05:31Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
13:48Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
Published on: April 21, 2023
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease V: Interprofessional Care
Cardiac Catheterization III: Left Heart Catheterization
Acute Coronary Syndrome III: Diagnostic Studies
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation