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Case Report: Can Inhaled Adenosine Attenuate COVID-19?
Bruce D Spiess1, Michael Sitkovsky2, Pierpaolo Correale3
1Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.
Frontiers in Pharmacology
|August 26, 2021
Summary
Inhaled adenosine showed rapid, positive effects in two severe COVID-19 patients in the US. This supports adenosine
Area of Science:
- Pulmonology
- Critical Care Medicine
- Pharmacology
Background:
- Investigated inhaled adenosine as a potential therapy for severe coronavirus disease-2019 (COVID-19).
- Explored the role of adenosine-regulator proteins in COVID-19 pathogenesis.
- Considered adenosine's anti-inflammatory and hypoxia signaling properties.
Observation:
- Two critically ill COVID-19 patients in the US, both with DNR/DNI status, received inhaled adenosine.
- Patients were not expected to survive prior to treatment.
- Inhaled adenosine administration is a potentially safe procedure, with prior use in asthmatic challenge testing.
Findings:
- Both patients experienced rapid and positive responses to inhaled adenosine.
- Observed effects align with pharmacological hypotheses regarding adenosine's role in COVID-19.
- Demonstrated potential therapeutic benefits of adenosine in severe respiratory infections.
Implications:
- Supports the hypothesis that adenosine plays a role in COVID-19.
- Suggests inhaled adenosine may be a viable therapeutic option for severe COVID-19.
- Highlights the importance of study repetition and replication in medical research.
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