Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study

Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings. Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12-18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively). Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15-18) adolescent boys who are carriers of the rs53576 GG variant. Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age-sex subgroups of adolescents.