Related Experiment Video
Updated: Oct 22, 2025
07:50
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
16.1K
Disseminated Gonococcal Infection: A Case Report of Arthritis-Dermatitis Syndrome
Mariana da Cruz1, Nuno Zarcos Palma1, Rita Veiga Ferraz2
1Internal Medicine Service, Centro Hospitalar Tamega e Sousa, Penafiel, Portugal.
Journal of Medical Cases
|August 26, 2021
Summary
Disseminated gonococcal infection (DGI) is a serious complication of gonorrhea. Early diagnosis and treatment with ceftriaxone are crucial for recovery, especially with rising antimicrobial resistance.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- * *Neisseria gonorrhoeae* ( *N. gonorrhoeae* ) can spread through the bloodstream, causing disseminated gonococcal infection (DGI).
- * DGI presents with diverse symptoms including skin lesions, tenosynovitis, and arthritis.
- * Drug-resistant *N. gonorrhoeae*, particularly cephalosporin resistance, is an urgent public health threat.
- * Antimicrobial resistance necessitates awareness of DGI's reemerging nature.
Observation:
- * A young woman presented to the emergency department with malaise and multiple skin lesions.
- * Clinical suspicion for DGI was raised based on presenting symptoms.
- * Diagnostic confirmation included blood cultures, cervical mucosa NAAT, and urine gonococcal probe.
Findings:
- * Blood cultures confirmed bacteremic spread of *N. gonorrhoeae*.
- * Nucleic acid amplification testing (NAAT) further supported the diagnosis.
- * Intravenous ceftriaxone treatment for one week resulted in complete clinical and analytical resolution.
Implications:
- * This case highlights the importance of recognizing DGI signs and symptoms.
- * Prompt diagnosis and appropriate antibiotic therapy are vital for patient recovery.
- * Clinicians must remain vigilant for this rare but reemerging infectious disease.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.8K
01:23Rheumatic Heart Disease I: Introduction
118
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
118
01:25Endocarditis II: Clinical Features of Infective Endocarditis
50
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
50
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
133
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
133
01:24Nephrotic Syndrome I : Introduction
201
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
201
01:25Endocarditis I: Introduction
78
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
78