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The Parathyroid Glands00:59

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Related Experiment Video

Updated: Oct 22, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Primary Hyperparathyroidism in Pregnancy: A Case Report.

Cristina Zanardini1, Rossana Orabona1,2, Sonia Zatti1

  • 1Obstetrics and Gynecology, ASST Spedali Civili, Brescia, Italy.

Journal of Medical Cases
|August 26, 2021
PubMed
Summary

Primary hyperparathyroidism (PHP) in pregnancy, a rare endocrine disorder, was successfully managed in a 28-year-old woman. Surgical removal of a parathyroid adenoma resolved hypercalcemia, ensuring a healthy pregnancy outcome.

Keywords:
HypercalcemiaNeuroendocrine tumorParathyroidectomyPregnancyPrimary hyperparathyroidism

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Area of Science:

  • Endocrinology
  • Obstetrics & Gynecology
  • Surgical Case Report

Background:

  • Primary hyperparathyroidism (PHP) is the third most common endocrine disorder, but its occurrence during pregnancy is rare.
  • Hypercalcemia in pregnancy can present with non-specific symptoms, complicating diagnosis.
  • Multidisciplinary management is crucial for addressing hypercalcemia in pregnant patients.

Observation:

  • A 28-year-old woman presented at 11 weeks gestation with weakness, hyperemesis gravidarum, and hypercalcemia.
  • Elevated parathyroid hormone levels correlated with hypercalcemia.
  • Neck computed tomography identified a solitary parathyroid adenoma (6 × 2.9 × 11 mm).

Findings:

  • Ultrasound-guided fine needle aspiration suggested a benign parathyroid tumor.
  • Left superior parathyroidectomy was performed.
  • Histopathological and immunohistochemical analyses confirmed parathyroid adenoma.

Implications:

  • Surgical intervention led to immediate and permanent resolution of hypercalcemia.
  • The postoperative course was uneventful, indicating successful management.
  • This case highlights the diagnostic challenges and successful treatment of hypercalcemia due to parathyroid adenoma during pregnancy.