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Copper Deficiency Myeloneuropathy in Autoimmune Disease.

Jonathan T Grossman¹, Steven Ruiz²

¹Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

|August 26, 2021

Summary

Copper deficiency can cause myeloneuropathy, mimicking vitamin B12 deficiency. This case highlights systemic sclerosis as a potential cause of copper deficiency, offering a treatable diagnosis.

Keywords:

auto-immune copper deficiency copper-induced myelopathy diffuse systemic sclerosis myeloneuropathy serum vitamin b12 subacute combined degeneration tabes dorsalis

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Area of Science:

Neurology
Nutritional Science
Immunology

Background:

Copper deficiency is a rare but treatable cause of myeloneuropathy.
Acquired copper deficiency often results from malabsorption (e.g., gastric surgery) or excessive zinc intake.
Clinical symptoms can resemble vitamin B12 deficiency, affecting the dorsal spinal cord.

Observation:

A 76-year-old female presented with myeloneuropathy.
The patient had advanced systemic sclerosis (SSc).

Findings:

The patient's myeloneuropathy was presumed to be a consequence of copper deficiency.
Systemic sclerosis is identified as a potential underlying cause for copper deficiency in this case.

Implications:

Recognizing copper deficiency myeloneuropathy is crucial for timely diagnosis and treatment.
Systemic sclerosis should be considered in the differential diagnosis of copper deficiency, especially when myeloneuropathy is present.
This case broadens the understanding of systemic sclerosis complications and the etiology of copper deficiency.