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BMP antagonists in tissue development and disease.

Annkatrin Correns1,2, Laura-Marie A Zimmermann1,2, Clair Baldock3,4

  • 1Department of Paediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

Matrix Biology Plus
|August 26, 2021
PubMed
Summary
This summary is machine-generated.

Bone morphogenic proteins (BMPs) are regulated by extracellular antagonists crucial for development and tissue homeostasis. Interactions targeting these BMP antagonists to the ECM influence their activity in development and disease.

Keywords:
ALK3, anaplastic lymphoma kinase 3ATF2, activating transcription factor 2ActR, activin receptorBDB2, brachydactyly type B2BISC, BMP-induced signalling complexBMP antagonistsBMPER, BMP binding endothelial regulatorBMPs, bone morphogenetic proteinsBone morphogenetic protein (BMP)CAN, cerberus and DANCDD, craniodiaphyseal dysplasiaCHRD domain, chordin specific domainCUB domain, for complement C1r/C1s, Uegf, Bmp1 domainConnective tissue disorderCv2, crossveinless-2DAN, differential screening selected gene aberrative in neuroblastomaDSD, diaphanospondylodysostosisDpp, decapentaplegicECM, extracellular matrixERK, extracellular signal-regulated kinasesExtracellular matrix (ECM)FMF, fibrillin microfibrilsHS, heparan sulphateHSPGs, heparan sulphate proteoglycansMAPKs, mitogen-activated protein kinasesMGC1, megalocornea 1PI3K, phosphoinositide 3-kinasePRDC, protein related to DAN and CerberusSOST, sclerostinSYNS1, multiple synostoses syndrome 1Scw, screwSog, short gastrulationTCC, tarsal-carpal coalition syndromeTGF-β, transforming growth factor- βTld, tolloidTsg, twisted gastrulationVBCH, Van Buchem diseaseXlr/Tll, xolloid-related metalloproteasevWC, von Willebrand factor type CvWD, von Willebrand factor type D

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Bone morphogenic proteins (BMPs) are vital regulators of embryonic development and adult tissue homeostasis.
  • BMP inhibition by extracellular antagonists is a key regulatory mechanism studied for developmental processes.
  • BMP antagonists are essential for extracellular matrix homeostasis, and their inactivation causes connective tissue disorders.

Purpose of the Study:

  • To focus on functional interactions targeting BMP antagonists to the extracellular matrix (ECM).
  • To discuss how these ECM interactions influence BMP antagonist activity.
  • To provide an overview of current concepts and mechanisms modulating BMP inhibitor function in development and disease.

Main Methods:

  • Literature review and synthesis of existing research on BMP antagonists and their ECM interactions.
  • Analysis of functional interactions targeting BMP antagonists to the ECM.
  • Overview of molecular mechanisms modulating BMP inhibitor function.

Main Results:

  • BMP antagonists interact with the ECM, influencing their availability and activity.
  • ECM targeting affects BMP signaling gradients critical for development.
  • Dysregulation of BMP antagonist-ECM interactions contributes to connective tissue disorders.

Conclusions:

  • ECM interactions are critical for regulating BMP antagonist function.
  • Understanding these interactions provides insights into developmental processes and diseases.
  • Further research into BMP antagonist-ECM modulation holds therapeutic potential.