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Related Experiment Videos

A speculative on psoriasis as an evolutionary consequence.

O J Stone1

  • 1Department of Dermatology, University of California at Irvine College of Medicine.

International Journal of Dermatology
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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Human inflammatory responses likely follow a bell curve, with psoriasis representing the most reactive 3%. Evolutionarily reducing inflammation may cause issues worse than psoriasis, suggesting quantitative, not qualitative, changes in psoriasis inflammation.

Area of Science:

  • Immunology
  • Evolutionary Biology
  • Dermatology

Background:

  • Inflammatory responses in humans are highly variable.
  • Psoriasis is characterized by heightened inflammatory activity.

Purpose of the Study:

  • To propose a theoretical framework for understanding inflammatory variation in humans.
  • To contextualize the inflammatory basis of psoriasis within a broader evolutionary perspective.

Main Methods:

  • Speculative analysis based on hypothetical quantitation of inflammatory reactivity.
  • Theoretical modeling of evolutionary pressures on inflammatory responses.

Main Results:

  • Hypothesizes that human inflammatory reactivity follows a normal distribution (bell-shaped curve).

Related Experiment Videos

  • Identifies the top 3% of reactivity as potentially associated with psoriasis or psoriatic traits.
  • Suggests that evolutionary selection for reduced general inflammation could have severe, unforeseen consequences.

    • Conclusions:

    • The observed inflammatory profile in psoriasis may be an evolutionary trade-off.
    • Future research may focus on quantitative rather than qualitative aspects of inflammation in psoriasis management.