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Updated: Oct 22, 2025

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Plasmonic gold nanostructures for biosensing and bioimaging.

Xiaowen Ou1,2, Yuqi Liu1, Mingxing Zhang1

  • 1Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Active Ingredients, Department of Chemistry and Life Science, Hubei University of Education, Wuhan, 430205, China.

Mikrochimica Acta
|August 26, 2021
PubMed
Summary

Plasmonic gold nanostructures offer unique optical properties for advanced biosensing and bioimaging applications. This review covers their use in vitro and in vivo techniques, highlighting their potential in diagnostics and medical imaging.

Keywords:
BioimagingBiosensingGold nanostructurePhotoacousticPhotothermalPlasmonScattering

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Optical Physics

Background:

  • Noble metal nanostructures, specifically gold, exhibit unique optical properties.
  • These gold nanostructures are biocompatible, stable, and multifunctional.
  • Their properties make them ideal for biosensing and bioimaging.

Purpose of the Study:

  • To review the optical properties of plasmonic gold nanostructures.
  • To summarize in vitro biosensing applications.
  • To briefly cover in vivo bioimaging applications.

Main Methods:

  • Localized Surface Plasmon Resonance (LSPR)
  • Rayleigh scattering
  • Surface-enhanced fluorescence and Raman scattering
  • Scattering, photothermal, and photoacoustic imaging

Main Results:

  • Plasmonic gold nanostructures demonstrate significant potential in various biosensing techniques.
  • These nanostructures are effective for in vitro detection and in vivo imaging.
  • The review synthesizes current applications and future outlooks.

Conclusions:

  • Plasmonic gold nanostructures are versatile tools for biosensing and bioimaging.
  • Their unique optical and physical properties drive innovation in medical diagnostics.
  • Further research promises expanded applications in healthcare.