Time-varying measures of cerebral network centrality correlate with visual saliency during movie watching

The extensive development of graph-theoretic analysis for functional connectivity has revealed the multifaceted characteristics of brain networks. Network centralities identify the principal functional regions, individual differences, and hub structure in brain networks. Neuroimaging studies using movie-watching have investigated brain function under naturalistic stimuli. Visual saliency is one of the promising measures for revealing cognition and emotions driven by naturalistic stimuli. This study investigated whether the visual saliency in movies was associated with network centrality. The study examined eigenvector centrality (EC), which is a measure of a region's influence in the brain network, and the participation coefficient (PC), which reflects the hub structure in the brain, was used for comparison. Static and time-varying EC and PC were analyzed by a parcel-based technique. While EC was correlated with brain activity in parcels in the visual and auditory areas during movie-watching, it was only correlated with parcels in the visual areas in the retinotopy task. In addition, high PC was consistently observed in parcels in the putative hub both during the tasks and the resting-state condition. Time-varying EC in the parietal parcels and time-varying PC in the primary sensory parcels significantly correlated with visual saliency in the movies. These results suggest that time-varying centralities in brain networks are distinctively associated with perceptual processing and subsequent higher processing of visual saliency.