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Updated: Jul 31, 2026
High-throughput Detection Method for Influenza Virus
Published on: February 4, 2012
Human bocavirus-1 screening in infants with acute lower respiratory tract infection
Xingang Zhang1, Jishan Zheng1, Lihua Zhu1
1Ningbo Women and Children's Hospital, Ningbo City, Zhejiang Province, China.
Insights
Human bocavirus (HBoV) is frequently detected in infants with acute lower respiratory tract infections (ALRTI) in China, particularly during winter. Co-infections are common, especially in severe cases.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Epidemiology
Background:
- Human bocavirus (HBoV) is increasingly associated with pediatric respiratory illnesses.
- Limited epidemiological data exists for HBoV infections specifically in infants.
- This study addresses the knowledge gap regarding HBoV in infants with ALRTI in eastern China.
Purpose of the Study:
- To investigate the prevalence of HBoV in infants diagnosed with ALRTI.
- To describe the clinical characteristics and epidemiological patterns of HBoV infection in this population.
- To identify common co-infections associated with HBoV in infants.
Main Methods:
- Prospective study design involving infants with ALRTI and age-matched healthy controls.
- Sample collection via nasopharyngeal aspirates and throat swabs from January 2016 to December 2019.
- HBoV detection using polymerase chain reaction (PCR); analysis of clinical and laboratory data.
Main Results:
- HBoV was detected in 145 out of 2510 infants with ALRTI; no HBoV was found in the control group.
- Peak HBoV prevalence occurred during winter months, with frequent co-infections observed.
- Common clinical manifestations included cough, wheezing, fever, and respiratory distress; co-pathogens identified.
Conclusions:
- HBoV is a significant pathogen in infants with ALRTI in eastern China.
- Winter seasonality and co-infections, particularly in ICU-admitted infants, are key epidemiological features.
- Timely and comprehensive clinical assessment is crucial for managing HBoV-associated ALRTI in infants.
Background:
Recent studies have reported associations between, human bocavirus (HBoV), and respiratory tract diseases in children. However, there is limited information on the epidemiology of HBoV in infants. This prospective study investigated the prevalence and clinical characteristics of HBoV infection in infants with acute lower respiratory tract infection (ALRTI) in eastern China.
Methods:
Nasopharyngeal aspirates and throat swab samples were collected from infants with ALRTI and age-matched healthy infants between January 2016 and December 2019. HBoV was identified by polymerase chain reaction. Laboratory data and clinical characteristics were analyzed.
Results:
Of 2510 infants, 145 tested positive for HBoV. The highest prevalence of HBoV was detected during the winter. Co-infection was frequently observed during this period of high viral transmission. There were no HBoV-positive infants in the control group. Clinical signs and symptoms included cough, wheezing, fever, nasal discharge, vomiting, diarrhea, hypoxemia, and tachypnea. Co-infections included: Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, Chlamydophila pneumoniae, respiratory syncytial virus, and adenovirus.
Conclusions:
HBoV was frequently detected in infants with ALRTI in China. The prevalence of HBoV was highest in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Comprehensive clinical evaluation may facilitate optimal treatment.
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