Advancing Academic Cancer Clinical Trials Recruitment in Canada

Area of Science:

• Oncology
• Clinical Research
• Health Services Research

Background:

• Academic cancer clinical trials (ACCT) activity faced a decline.
• The Canadian Cancer Clinical Trials Network (3CTN) was established in 2014 to address this issue.
• Funding models were implemented to support ACCTs across Canadian cancer centers.

Purpose of the Study:

• To evaluate the effectiveness of the 3CTN in increasing ACCT activity.
• To identify factors predicting successful patient recruitment in ACCTs.
• To assess the impact of the 3CTN on cancer trial access and patient outcomes.

Main Methods:

• A portfolio approach to funding cancer centers for ACCTs.
• Implementation of core and incentive-based funding structures.
• Tracking of established performance measures, including patient recruitment.
• Statistical analysis to identify success factors for recruitment targets.

Main Results:

• From 2014-2018, 11,275 patients were recruited to 559 trials.
• Overall recruitment increased by 59.6% above the pre-3CTN baseline by Year 4.
• The overall recruitment target was achieved within three years, with 51% of adult centers meeting the Year 4 target.
• Time period, region, and number of baseline trials were identified as key factors for achieving recruitment targets.

Conclusions:

• The 3CTN successfully met its objectives for increasing ACCT activity.
• The network demonstrated a significant positive impact on patient recruitment and trial access.
• Continued support and funding are recommended to sustain and enhance ACCTs for improved patient outcomes.