Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation

Area of Science:

• Neuroscience
• Biotechnology
• Bioengineering

Background:

• Magnetogenetics enables remote control of cellular activity using electromagnetic fields.
• Developing effective magnetogenetic tools requires specialized hardware for precise stimulation.
• Existing systems may lack versatility for diverse experimental setups.

Purpose of the Study:

• To present a universal stimulus delivery system for magnetogenetics.
• To design compatible magnet configurations for various experimental modalities.
• To develop a precise and reproducible stimulation control system.

Main Methods:

• Designed four novel electromagnet configurations for magnetogenetics.
• Integrated a low-cost stimulation controller for rapid switching and precise control.
• Tested system compatibility with electrophysiology, fluorescence/luminescence imaging, and microscopy.

Main Results:

• The system supports electrophysiology, fluorescence, luminescence imaging, and microscopy.
• The controller allows for rapid switching between active and sham stimulation.
• The hardware enables repeatable and reproducible measurements in magnetogenetics experiments.

Conclusions:

• The presented universal stimulus delivery system advances magnetogenetics research.
• The versatile hardware and controller facilitate diverse experimental applications.
• This system enhances the reproducibility and accessibility of magnetogenetic studies.