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An Adjustable Dark-Field Acoustic-Resolution Photoacoustic Imaging System with Fiber Bundle-Based Illumination.

Yuhling Wang1, De-Fu Jhang1,2, Tsung-Sheng Chu1,2

  • 1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053, Taiwan.

Biosensors
|August 26, 2021
PubMed
Summary

A new compact photoacoustic (PA) imaging probe uses adjustable optical fibers for versatile preclinical studies. This alignment-free design offers high-resolution structural and functional imaging without bulky components.

Keywords:
fiber-bundle-based illuminationhemoglobin oxygenation saturationin vivo imagingphotoacoustic (PA)

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Area of Science:

  • Biomedical Imaging
  • Optical Engineering
  • Acoustic Imaging

Background:

  • Photoacoustic (PA) imaging offers high resolution and structural information in biological tissues.
  • Current PA systems are often bulky due to lasers or complex optical components.
  • There is a need for compact, versatile PA imaging probes for preclinical research.

Purpose of the Study:

  • To develop a robust, compact acoustic-resolution PA imaging system.
  • To create an alignment-free PA probe with adjustable optical fibers.
  • To demonstrate the system's performance in various in vitro and in vivo preclinical applications.

Main Methods:

  • Designed a PA probe with four adjustable optical fibers around a 50 MHz ultrasound transducer.
  • Implemented a MATLAB-based user interface for parameter adjustment.
  • Validated the system using in vitro phantoms and in vivo rat models (ear vasculature, SSS hemodynamics, ICG dynamics).

Main Results:

  • The compact PA probe demonstrated adjustable illumination parameters for diverse applications.
  • Successful in vitro phantom imaging was achieved.
  • In vivo imaging of rat ear vasculature, cortical hemodynamics, and cerebral ICG dynamics was demonstrated in real-time.

Conclusions:

  • The developed alignment-free, compact PA probe design addresses limitations of current commercial systems.
  • This versatile system is suitable for a wide range of preclinical PA imaging needs.
  • The probe's design facilitates easier integration and application in research settings.